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The trail of a mysterious organization called the "Army of the 12 Monkeys" leads Cole to a mental institution in 2015, where a patient holds the key to the plague that destroys the world. Meanwhile, despite warnings that her involvement may disrupt the course of history, Dr. Railly risks her life to help him.
Katarina Jones and her staff listen to Cassandra Railly's recorded message. They realize for the first time that the message contains a reference to the Army of the 12 Monkeys. Jones decides to send Cole and Ramse to look at a mental institution where the symbol of the Army appeared.
- The title is a reference to a character in the 1995 film, a psychiatric patient who tells James Cole that he is "mentally divergent", able to go to imaginary worlds in his mind.
- Katarina Jones: "Time is cruel Mr. Cole. We are risking everything by toying with it, taunting it. Believe me, I’ve learned enough about time to fear it and so should you."
- Katarina Jones: "Mr. Cole's name was on a recording from 30 years go. Fate gave your friend this mission. You, Mr. Ramse, are here only because he insists on it. Do you understand the difference? Your future is not pre-ordained."